PittsburghV1, Main, Exploration, bibRecord, 001A19

Predictors and Moderators of Treatment Response in Childhood Anxiety Disorders: Results from the CAMS Trial

Identifieur interne : 001A19 ( Main/Exploration ); précédent : 001A18; suivant : 001A20

Predictors and Moderators of Treatment Response in Childhood Anxiety Disorders: Results from the CAMS Trial

Auteurs : Scott N. Compton ; Tara S. Peris ; Daniel Almirall ; Boris Birmaher ; Joel Sherrill ; Phillip C. Kendall ; John S. March ; Elizabeth A. Gosch ; Golda S. Ginsburg ; Moira A. Rynn ; John C. Piacentini ; James T. Mccracken ; Courtney P. Keeton ; Cynthia M. Suveg ; Sasha G. Aschenbrand ; Dara Sakolsky ; Satish Iyengar ; John T. Walkup ; Anne Marie Albano

Source :

Journal of consulting and clinical psychology [ 0022-006X ] ; 2014.

RBID : PMC:4056442

Descripteurs français

KwdFr :
- Adolescent, Association thérapeutique, Enfant, Facteurs socioéconomiques, Femelle, Humains, Inhibiteurs de la capture de la sérotonine (usage thérapeutique), Mâle, Résultat thérapeutique, Sertraline (usage thérapeutique), Thérapie cognitive (), Troubles anxieux (), Troubles anxieux (psychologie), Troubles anxieux (traitement médicamenteux).
MESH :
- psychologie : Troubles anxieux.
- traitement médicamenteux : Troubles anxieux.
- usage thérapeutique : Inhibiteurs de la capture de la sérotonine, Sertraline.
- Adolescent, Association thérapeutique, Enfant, Facteurs socioéconomiques, Femelle, Humains, Mâle, Résultat thérapeutique, Thérapie cognitive, Troubles anxieux.

English descriptors

KwdEn :
- Adolescent, Anxiety Disorders (drug therapy), Anxiety Disorders (psychology), Anxiety Disorders (therapy), Child, Cognitive Therapy (methods), Combined Modality Therapy, Female, Humans, Male, Serotonin Uptake Inhibitors (therapeutic use), Sertraline (therapeutic use), Socioeconomic Factors, Treatment Outcome.
MESH :
- chemical , therapeutic use : Serotonin Uptake Inhibitors, Sertraline.
- drug therapy : Anxiety Disorders.
- methods : Cognitive Therapy.
- psychology : Anxiety Disorders.
- therapy : Anxiety Disorders.
- Adolescent, Child, Combined Modality Therapy, Female, Humans, Male, Socioeconomic Factors, Treatment Outcome.

Abstract

Objective

To examine predictors and moderators of treatment outcomes among 488 youth ages 7-17 years (50% female; 74% ≤ 12 years) with DSM-IV diagnoses of separation anxiety disorder, social phobia, or generalized anxiety disorder who were randomly assigned to receive either cognitive behavior therapy (CBT), sertraline (SRT), their combination (COMB), or medication management with pill placebo (PBO) in the Child/Adolescent Anxiety Multimodal Study (CAMS).

Method

Six classes of predictor and moderator variables (22 variables) were identified from the literature and examined using continuous (Pediatric Anxiety Ratings Scale; PARS) and categorical (Clinical Global Impression Scale-Improvement; CGI-I) outcome measures.

Results

Three baseline variables predicted better outcomes (independent of treatment condition) on the PARS, including low anxiety severity (as measured by parents and independent evaluators) and caregiver strain. No baseline variables were found to predict week 12 responder status (CGI-I). Participant's principal diagnosis moderated treatment outcomes, but only on the PARS. No baseline variables were found to moderate treatment outcomes on week 12 responder status (CGI-I).

Discussion

Overall, anxious children responded favorably to CAMS treatments. However, having more severe and impairing anxiety, greater caregiver strain, and a principal diagnosis of social phobia were associated with less favorable outcomes. Clinical implications of these findings are discussed.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056442

DOI: 10.1037/a0035458
PubMed: 24417601
PubMed Central: 4056442

Affiliations:

Le document en format XML

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<wicri:noCountry code="subfield">Weill Cornell Medical College</wicri:noCountry>
</affiliation>
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<wicri:noCountry code="subfield">Duke University Medical Center</wicri:noCountry>
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<wicri:noCountry code="subfield">University of California at Los Angeles</wicri:noCountry>
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<wicri:noCountry code="subfield">University of Michigan</wicri:noCountry>
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<author><name sortKey="Gosch, Elizabeth A" sort="Gosch, Elizabeth A" uniqKey="Gosch E" first="Elizabeth A." last="Gosch">Elizabeth A. Gosch</name>
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<wicri:noCountry code="subfield">Philadelphia College of Osteopathic Medicine</wicri:noCountry>
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<author><name sortKey="Ginsburg, Golda S" sort="Ginsburg, Golda S" uniqKey="Ginsburg G" first="Golda S." last="Ginsburg">Golda S. Ginsburg</name>
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<wicri:noCountry code="subfield">The Johns Hopkins Hospital</wicri:noCountry>
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<author><name sortKey="Rynn, Moira A" sort="Rynn, Moira A" uniqKey="Rynn M" first="Moira A." last="Rynn">Moira A. Rynn</name>
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<wicri:noCountry code="subfield">Columbia University Medical Center</wicri:noCountry>
</affiliation>
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<author><name sortKey="Piacentini, John C" sort="Piacentini, John C" uniqKey="Piacentini J" first="John C." last="Piacentini">John C. Piacentini</name>
<affiliation><nlm:aff id="A2">Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles</nlm:aff>
<wicri:noCountry code="subfield">University of California at Los Angeles</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mccracken, James T" sort="Mccracken, James T" uniqKey="Mccracken J" first="James T." last="Mccracken">James T. Mccracken</name>
<affiliation><nlm:aff id="A2">Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles</nlm:aff>
<wicri:noCountry code="subfield">University of California at Los Angeles</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Keeton, Courtney P" sort="Keeton, Courtney P" uniqKey="Keeton C" first="Courtney P." last="Keeton">Courtney P. Keeton</name>
<affiliation><nlm:aff id="A8">Division of Child and Adolescent Psychiatry, The Johns Hopkins Hospital</nlm:aff>
<wicri:noCountry code="subfield">The Johns Hopkins Hospital</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Suveg, Cynthia M" sort="Suveg, Cynthia M" uniqKey="Suveg C" first="Cynthia M." last="Suveg">Cynthia M. Suveg</name>
<affiliation><nlm:aff id="A10">Department of Psychology, University of Georgia</nlm:aff>
<wicri:noCountry code="subfield">University of Georgia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Aschenbrand, Sasha G" sort="Aschenbrand, Sasha G" uniqKey="Aschenbrand S" first="Sasha G." last="Aschenbrand">Sasha G. Aschenbrand</name>
<affiliation><nlm:aff id="A9">Department of Child Psychiatry, Columbia University Medical Center</nlm:aff>
<wicri:noCountry code="subfield">Columbia University Medical Center</wicri:noCountry>
</affiliation>
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<author><name sortKey="Sakolsky, Dara" sort="Sakolsky, Dara" uniqKey="Sakolsky D" first="Dara" last="Sakolsky">Dara Sakolsky</name>
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<wicri:noCountry code="subfield">University of Pittsburgh Medical Center</wicri:noCountry>
</affiliation>
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<author><name sortKey="Iyengar, Satish" sort="Iyengar, Satish" uniqKey="Iyengar S" first="Satish" last="Iyengar">Satish Iyengar</name>
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<wicri:noCountry code="subfield">University of Pittsburgh Medical Center</wicri:noCountry>
</affiliation>
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<author><name sortKey="Walkup, John T" sort="Walkup, John T" uniqKey="Walkup J" first="John T." last="Walkup">John T. Walkup</name>
<affiliation><nlm:aff id="A11">Division of Child and Adolescent Psychiatry, Weill Cornell Medical College</nlm:aff>
<wicri:noCountry code="subfield">Weill Cornell Medical College</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Albano, Anne Marie" sort="Albano, Anne Marie" uniqKey="Albano A" first="Anne Marie" last="Albano">Anne Marie Albano</name>
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<wicri:noCountry code="subfield">Columbia University Medical Center</wicri:noCountry>
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<term>Anxiety Disorders (drug therapy)</term>
<term>Anxiety Disorders (psychology)</term>
<term>Anxiety Disorders (therapy)</term>
<term>Child</term>
<term>Cognitive Therapy (methods)</term>
<term>Combined Modality Therapy</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Serotonin Uptake Inhibitors (therapeutic use)</term>
<term>Sertraline (therapeutic use)</term>
<term>Socioeconomic Factors</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Association thérapeutique</term>
<term>Enfant</term>
<term>Facteurs socioéconomiques</term>
<term>Femelle</term>
<term>Humains</term>
<term>Inhibiteurs de la capture de la sérotonine (usage thérapeutique)</term>
<term>Mâle</term>
<term>Résultat thérapeutique</term>
<term>Sertraline (usage thérapeutique)</term>
<term>Thérapie cognitive ()</term>
<term>Troubles anxieux ()</term>
<term>Troubles anxieux (psychologie)</term>
<term>Troubles anxieux (traitement médicamenteux)</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Serotonin Uptake Inhibitors</term>
<term>Sertraline</term>
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<term>Child</term>
<term>Combined Modality Therapy</term>
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<term>Association thérapeutique</term>
<term>Enfant</term>
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<term>Femelle</term>
<term>Humains</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">To examine predictors and moderators of treatment outcomes among 488 youth ages 7-17 years (50% female; 74% ≤ 12 years) with DSM-IV diagnoses of separation anxiety disorder, social phobia, or generalized anxiety disorder who were randomly assigned to receive either cognitive behavior therapy (CBT), sertraline (SRT), their combination (COMB), or medication management with pill placebo (PBO) in the Child/Adolescent Anxiety Multimodal Study (CAMS).</p>
</sec>
<sec id="S2"><title>Method</title>
<p id="P2">Six classes of predictor and moderator variables (22 variables) were identified from the literature and examined using continuous (Pediatric Anxiety Ratings Scale; PARS) and categorical (Clinical Global Impression Scale-Improvement; CGI-I) outcome measures.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Three baseline variables predicted better outcomes (independent of treatment condition) on the PARS, including low anxiety severity (as measured by parents and independent evaluators) and caregiver strain. No baseline variables were found to predict week 12 responder status (CGI-I). Participant's principal diagnosis moderated treatment outcomes, but only on the PARS. No baseline variables were found to moderate treatment outcomes on week 12 responder status (CGI-I).</p>
</sec>
<sec id="S4"><title>Discussion</title>
<p id="P4">Overall, anxious children responded favorably to CAMS treatments. However, having more severe and impairing anxiety, greater caregiver strain, and a principal diagnosis of social phobia were associated with less favorable outcomes. Clinical implications of these findings are discussed.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Albano, Anne Marie" sort="Albano, Anne Marie" uniqKey="Albano A" first="Anne Marie" last="Albano">Anne Marie Albano</name>
<name sortKey="Almirall, Daniel" sort="Almirall, Daniel" uniqKey="Almirall D" first="Daniel" last="Almirall">Daniel Almirall</name>
<name sortKey="Aschenbrand, Sasha G" sort="Aschenbrand, Sasha G" uniqKey="Aschenbrand S" first="Sasha G." last="Aschenbrand">Sasha G. Aschenbrand</name>
<name sortKey="Birmaher, Boris" sort="Birmaher, Boris" uniqKey="Birmaher B" first="Boris" last="Birmaher">Boris Birmaher</name>
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<name sortKey="Ginsburg, Golda S" sort="Ginsburg, Golda S" uniqKey="Ginsburg G" first="Golda S." last="Ginsburg">Golda S. Ginsburg</name>
<name sortKey="Gosch, Elizabeth A" sort="Gosch, Elizabeth A" uniqKey="Gosch E" first="Elizabeth A." last="Gosch">Elizabeth A. Gosch</name>
<name sortKey="Iyengar, Satish" sort="Iyengar, Satish" uniqKey="Iyengar S" first="Satish" last="Iyengar">Satish Iyengar</name>
<name sortKey="Keeton, Courtney P" sort="Keeton, Courtney P" uniqKey="Keeton C" first="Courtney P." last="Keeton">Courtney P. Keeton</name>
<name sortKey="Kendall, Phillip C" sort="Kendall, Phillip C" uniqKey="Kendall P" first="Phillip C." last="Kendall">Phillip C. Kendall</name>
<name sortKey="March, John S" sort="March, John S" uniqKey="March J" first="John S." last="March">John S. March</name>
<name sortKey="Mccracken, James T" sort="Mccracken, James T" uniqKey="Mccracken J" first="James T." last="Mccracken">James T. Mccracken</name>
<name sortKey="Peris, Tara S" sort="Peris, Tara S" uniqKey="Peris T" first="Tara S." last="Peris">Tara S. Peris</name>
<name sortKey="Piacentini, John C" sort="Piacentini, John C" uniqKey="Piacentini J" first="John C." last="Piacentini">John C. Piacentini</name>
<name sortKey="Rynn, Moira A" sort="Rynn, Moira A" uniqKey="Rynn M" first="Moira A." last="Rynn">Moira A. Rynn</name>
<name sortKey="Sakolsky, Dara" sort="Sakolsky, Dara" uniqKey="Sakolsky D" first="Dara" last="Sakolsky">Dara Sakolsky</name>
<name sortKey="Sherrill, Joel" sort="Sherrill, Joel" uniqKey="Sherrill J" first="Joel" last="Sherrill">Joel Sherrill</name>
<name sortKey="Suveg, Cynthia M" sort="Suveg, Cynthia M" uniqKey="Suveg C" first="Cynthia M." last="Suveg">Cynthia M. Suveg</name>
<name sortKey="Walkup, John T" sort="Walkup, John T" uniqKey="Walkup J" first="John T." last="Walkup">John T. Walkup</name>
</noCountry>
</tree>
</affiliations>
</record>

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   |texte=   Predictors and Moderators of Treatment Response in Childhood Anxiety Disorders: Results from the CAMS Trial
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Predictors and Moderators of Treatment Response in Childhood Anxiety Disorders: Results from the CAMS Trial

Predictors and Moderators of Treatment Response in Childhood Anxiety Disorders: Results from the CAMS Trial

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